φX174 gene A protein does not cleave at a mouse mitochondrial DNA sequence homologous to the φX and G4 cleavage site |
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Authors: | Jackie N Doda David A Clayton |
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Abstract: | The light strand origin of replication of mouse mitochondrial DNA contains a 30-nucleotide region which is 60% homologous to the 30-nucleotide conserved sequence in φX174 and G4 viral DNAs known to contain the viral gene A protein cleavage site. Gene A protein does not cleave closed circular mouse mitochondrial DNA under conditions in which φX174 closed circular DNA is cleaved. |
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