Uptake and metabolism of 3′,5′-cyclic adenosine monophosphate and <em>N</em>,<em>O</em>′-dibutyryl 3′,5′-cyclic adenosine monophosphate in isolated bovine thyroid cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Uptake and metabolism of 3′,5′-cyclic adenosine monophosphate and N,O′-dibutyryl 3′,5′-cyclic adenosine monophosphate in isolated bovine thyroid cells

Authors:	M. SzaboG. Burke

Affiliation:	Division of Endocrinology and Nuclear Medicine, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Ill. 60616 U.S.A.

Abstract:	1. 1. Accumulation of intracellular radioactivity was measured during incubation of isolated bovine thyroid cells with cyclic [³²P]AMP, cyclic [8-³H]AMP and dibutyryl cyclic [8-³H]AMP. With cyclic [³²P]AMP, ³²P cell/medium ratios ranged from 0 to to 0.04 compared to a maximum ³H cell/medium ratio of 0.29 with cyclic [³H]AMP and 0.16 with dibutyryl cyclic [³H]AMP. The excess of intracellular cyclic [³H] over cyclic [³²P]AMP radioactivity was due to extracellular formation of more penetrable dephosphorylated cyclic AMP metabolites which probably served as precursor of intra-cellular cyclic AMP.

Keywords:	TSH thyrotropin
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