Angiotensin increases microsomal (Na−K-ATPase activity in several tissues |
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Authors: | Y GutmanY Shamir D GlushevitzkyS Hochman |
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Institution: | Department of Pharmacology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel |
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Abstract: | Angiotensin increased microsomal (Na+K+)-activated ATPase from rat hypothalamus, mucosa of colon and bovine adrenal cortex but not brain cortex. Angiotensin did not change significantly Mg2+-ATPase in these tissues. Enhancement by angiotensin was evident at concentrations of 10−8 − 10−12 M. In bovine adrenal cortex angiotensin increased ATPase activity in the outer and not in the inner layer. Angiotensin increased ATPase activity with Na+ above 20 mM and K+ above 5 mM present simultaneously, but not with either ion alone. |
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