Prostaglandin E2: Effects on aggregation,shape change and cyclic AMP of rat platelets |
| |
| Authors: | Hideo ShioPeter W. Ramwell Sheila J. Jessup |
| |
| Affiliation: | ALZA Corp., Palo Alto, Calif. 94304, USA |
| |
| Abstract: | PGE2 inhibits intracellular cyclic AMP accumulation induced by PGE1 in rat platelets. PGE2 also counteracts PGE1-inhibition of both platelet aggregation and shape change. However, in the presence of theophylline, PGE2 acts like PGE1 in inhibiting aggregation. The mechanism of interaction of the two closely related prostaglandins is discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
