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IL-4: an important cytokine in determining the fate of T cells |
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| Authors: | J. L. Silva-Filho C. Caruso-Neves A. A. S. Pinheiro |
| Affiliation: | 1. Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, boco C, sala 34, Av. Carlos Chagas Filho 373, 21941-902, Rio de Janeiro, RJ, Brazil 2. Instituto Nacional de Ciência e Tecnologia em Biologia e Bioimagem, Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT, Rio de Janeiro, Brazil 3. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Regi?o Amaz?nica, Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT, Rio de Janeiro, Brazil |
| Abstract: | The pleiotropic effect of cytokines has been well documented, but the effects triggered by unique cytokines in different T cell types are still under investigation. The most relevant findings on the influence of interleukin-4 (IL-4) on T cell activation, differentiation, proliferation, and survival of different T cell types are discussed in this review. The main aim of our study was to correlate the observed effect with the corresponding molecular mechanism induced on IL-4/IL-4R interaction, in an effort to understand how the same extracellular stimuli can trigger a wide spectrum of signaling pathways leading to different responses in each T cell type. |
| Keywords: | T cells Interleukin-4 Survival Differentiation Activation |
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