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Simple sugars inhibit proliferation of human T lymphocytes in autologous and allogeneic mixed lymphocyte reactions
Authors:F Licastro  M Chiricolo  P Tabacchi  C Franceschi
Institution:1. Institute of General Pathology, University of Bologna; Ospedale “M. Malpighi”, Bologna Italy;2. Chair of Immunology, University of Modena, Italy;1. Programa de Pós-Graduação em Zootecnia, Universidade Estadual de Mato Grosso do Sul, Unidade Universitária de Aquidauana, Rodovia Aquidauana-UEMS Km 12, Cx Postal 25, CEP 79200-000, Aquidauana, MS, Brazil;2. Department of Biology and CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal;3. University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, Vodnany, 389 25, Czech Republic;1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea;2. School of Life Sciences and Bio Imaging Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea;1. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14850, USA;2. Advanced Photon Source, Argonne National Laboratory, Lemont, IL 60439, USA;3. School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK;1. Department of Bioscience, Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime, 790-8566, Japan;2. Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime, 790-8566, Japan;3. Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama, Ehime, 790-8577, Japan
Abstract:Several oligo- and monosaccharides were studied for their capacity to modulate lymphocyte proliferation in human allogeneic and autologous mixed lymphocyte reactions (MLR). A defined subset of sugars showed a marked inhibitory effect on lymphocyte proliferative response in the majority of the allogeneic MLR combinations studied. The inhibitory effect disappeared when sugars were added to allogeneic MLR 96 hr after the beginning of culture. These sugars also showed a significant inhibitory power on autologous MLR, performed by using T- and non-T-enriched lymphocytes from the same donor. The reported data suggest that carbohydrate determinants are involved in the proliferative response of human lymphocytes in both autologous and allogeneic MLR.
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