The impact of the glial spatial buffering on the K+ Nernst potential |
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Authors: | H. R. Noori |
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Affiliation: | (1) Interdisciplinary Center for Scientific Computing, University of Heidelberg, Im Neuenheimer Feld 294, 69120 Heidelberg, Germany |
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Abstract: | Astrocytes play a critical role in CNS metabolism, regulation of volume and ion homeostasis of the interstitial space. Of special relevance is their clearance of K+ that is released by active neurons into the extracellular space. Mathematical analysis of a modified Nernst equation for the electrochemical equilibrium of neuronal plasma membranes, suggests that K+ uptake by glial cells is not only relevant during neuronal activity but also has a non-neglectable impact on the basic electrical membrane properties, specifically the resting membrane potential, of neurons and might be clinically valuable as a factor in the genetics and epigenetics of the epilepsy and tuberous sclerosis complex. |
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Keywords: | Tripartite synapse K+ spatial buffering Nernst equation Membrane potential |
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