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The anti-tumor effect of Newcastle disease virus HN protein is influenced by differential subcellular targeting |
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| Authors: | Hong Sui Yuxian Bai Kaibing Wang Xi Li Chun Song Fang Fu Yongxin Zhang Lejing Li |
| Affiliation: | (1) Medical Department, The Tumor Hospital Affiliated Harbin Medical University, Harbin, 150040, Heilongjiang, China;(2) Interventional Department, The Second Hospital Affiliated Harbin Medical University, Harbin, Heilongjiang, China;(3) Division of Swine Disease, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Medicine, Harbin, Heilongjiang, China;(4) The Key Laboratory of Cell Transplantation of Ministry of Health, The First Hospital Affiliated Harbin Medical University, Harbin, Heilongjiang, China; |
| Abstract: | BackgroundImmunotherapy is emerging as a major player in the current standard of care for aggressive cancers such as non-small cell lung cancer (NSCLC). The Newcastle disease virus with its tumor-specific replicative and oncolytic abilities is a promising immunotherapeutic candidate. A DNA vaccine expressing the major immunogenic hemagglutinin-neuraminidase (HN) protein of this virus has shown promising results as an immunotherapeutic agent. |
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