Combinatorial search of substituted beta-cyclodextrins for phosphatase-like activity. |
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| Authors: | J Yu Y Zhao M J Holterman D L Venton |
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| Institution: | Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, 60612, USA. |
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| Abstract: | Thirteen per-6-akylamino-6-deoxy-beta-cyclodextrin libraries (beta-CD libraries) were generated by a solution-phase combinatorial synthesis starting from per-6-iodo-6-deoxy-beta-CD and different combinations of eleven individual amine nucleophiles. Certain libraries showed the ability to hydrolyzep-nitrophenyl phosphate in the presence of Zn2+. |
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