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Close linkage of MEN2A with RBP3 locus in Japanese kindreds |
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| Authors: | Masayuki Yamamoto Shin-ichiro Takai Tetsuro Miki Kazuyoshi Motomura Makoto Okazaki Isamu Nishisho Hideo Tateishi Akira Miyauchi Tasuku Honjo A J Pakstis Takesada Mori |
| Affiliation: | (1) Second Department of Surgery, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, 553 Osaka, Japan;(2) Department of Medicine and Geriatrics, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, 553 Osaka, Japan;(3) Second Department of Surgery, Kagawa Medical School, Miki-cho, 761-07 Kagawa, Japan;(4) Department of Medical Chemistry, Kyoto University Faculty of Medicine, Yoshidakonoe-cho, 606 Kyoto, Japan;(5) Department of Human Genetics, Yale University School of Medicine, 06510 New Haven, CT, USA |
| Abstract: | Summary The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromsome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds. |
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