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Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies |
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| Authors: | Liu Mei Wang Sanyi Clampit Jill E Gum Rebecca J Haasch Deanna L Rondinone Cristina M Trevillyan James M Abad-Zapatero Cele Fry Elizabeth H Sham Hing L Liu Gang |
| Institution: | Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6098, USA. mei.liu@abbott.com |
| Abstract: | A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described. |
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