Rapid Growth Mutants of Escherichia Coli |
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| Authors: | James Canvin Susan Grant Primrose Freestone Istvan Toth Mirella Trinei Kishor Modha Dominique Cellier Vic Norris |
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| Institution: | (1) Department of Microbiology and Immunology, University of Leicester, Medical Sciences Building, 110 Box 138, Leicester, LE1 9HN, UK;(2) Laboratoire Analyse et Modèles Stochastiques UPRESA 6085, Faculté des Sciences et Techniques, Université de Rouen, F76821 Mont Saint Aignan Cedex, France;(3) Institut Fédératif de Recherche 'Systèmes Intégrés', Faculté des Sciences et Techniques, Université de Rouen, F76821 Mont saint Aignan, France |
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| Abstract: | If rapid growth (rap) mutants of Escherichia coli could be obtained, these might prove a valuable contribution to fields as diverse as growth rate control, biotechnology and the regulation of the bacterial cell cycle. To obtain rap mutants, a dnaQ mutator strain was grown for four and a half days continuously in batch culture. At the end of the selection period, there was no significant change in growth rate. This result means that selecting rap mutants may require an alternative strategy and a number of such alternatives are discussed. |
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