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DECREASED DENSITIES OF INTRAMEMBRANOUS PARTICLES AND CYTOCHEMICALLY DETECTABLE CHOLESTEROL IN MICROVILLI OF STARVED RAT ENTEROCYTES |
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| Authors: | A. A. WAHEED Y. TOYAMA F. YASUZUMI P. D. GUPTA |
| Affiliation: | 1. Centre for Cellular and Molecular Biology, Hyderabad, 500 007, India;2. Dept of Anatomy, Chiba University, Chiba, 280, Japan;3. 2nd Department of Anatomy, University of the Ryukyus, Okinawa, 903-01, Japan |
| Abstract: | The densities of intramembranous particles (IMPs) and of sterol complexes induced by treatment of filipin were studied by freeze-fracture replication of intact intestine and/or isolated brush border membranes (BBM) of well-fed and starved rats. The density of IMPs and filipin-sterol complexes (FSCs) decrease considerably during starvation. Biochemical estimations show a decrease in the levels of cholesterol and proteins with respect to phospholipids during starvation which is in agreement with morphological findings. It is suggested that these changes may play a role in regulating membrane fluidity which in turn affects absorption of nutrients through BBM. |
| Keywords: | rat intestine lasting brush border membranes freeze-fracture cholesterol protein phospholipid ratio |
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