Biotransformation of sterigmatocystin and absence of aflatoxin biotransformation by blocked mutants ofAspergillus parasiticus |
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| Institution: | 1. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;2. Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea;3. Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea;4. Department of Neurology, Sanggye Paik Hospital, Inje University, Seoul, Republic of Korea;5. Department of Neurology, Gil Medical Center, Gachon Medical School, Incheon, Republic of Korea |
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| Abstract: | Four blocked aflatoxin mutants were used to test biotransformation of sterigmatocystin and aflatoxins. Three blocked anthraquinone-accumulating mutants (avn-1, avr-1, ver-1) were able to convert sterigmatocystin into both B and G aflatoxins. No conversions of sterigmatocystin were observed with autoclaved controls or with the fourth blocked mutant (fan). Under equivalent resting cell conditions, no interconversion of aflatoxins B1, B2, G1, or G2 was observed byver-1, fan, or autoclaved controls. |
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