Comparison of day 2 and overnight day 3 frozen embryo transfers: A prospective randomized controlled trial |
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| Institution: | 1. Division of Reproductive Endocrinology and IVF, Department of Obstetrics and Gynecology, Lady Davis Carmel Medical Center, Haifa, Israel;2. Ruth and Bruch Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel;1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Obstetrics, Jingmen First People''s Hospital, Jingmen City, 448000, Hubei Province, China;2. Department of Gynecology, Jingmen First People''s Hospital, Jingmen City, 448000, Hubei Province, China;1. CNRS, IFCE, INRAE, Université de Tours, PRC, 37380, Nouzilly, France;2. Union Evolution, Noyal-Sur-Vilaine, France;3. INRAE, Université de Tours, CHU de Tours, PIXANIM, 37380 Nouzilly, France;4. INRAE, Université de Tours, ISP, 37380 Nouzilly, France;5. Tours University, Tours, France;1. Department of Obstetrics, The Maternity Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China;2. Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China;3. Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China;4. The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China;5. Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi, 530021, China;6. Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi, 530021, China;1. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China;2. Department of Biochemistry and Molecular Biology, GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China |
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| Abstract: | In certain patients cleavage stage embryos may be preferred. The relationship between an additional day in culture and pregnancy outcomes is not well established. We aimed to compare outcomes of day 2 versus overnight day 3 frozen embryo transfer (FET). In this randomized controlled trial, patients with day 2 cryopreserved embryos were allocated to two groups. In group A embryos were transferred on day 2, the same day of thawing. In group B embryos were transferred one day after thawing, on day 3 after overnight incubation. Out of 410 patients eligible, 92 were recruited. Finally, 72 patients participated, 39 in group A and 33 in group B. No significant difference in implantation (11 % in group A and 14 % in group B, p = 0.81), clinical pregnancy (18 % in group A and 21 % in group B, p = 0.73) or live birth rates (13 % in group A and 18 % in group B, p = 0.53) was found. To conclude, no significant difference in reproductive outcomes was found when comparing patients with day 2 or overnight day 3 FET. Considering published data on blastocyst transfer, cleavage stage ET may still be a relevant option and the decision between day 2 or overnight day 3 ET depends on patients’ and physicians’ preference and recommendation. |
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| Keywords: | Cleavage stage Implantation Pregnancy Frozen embryo transfer Live birth |
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