Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling |
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| Institution: | 1. Department of Cell Biology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China;2. Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China;1. Department of Neurosurgery, The Affiliated Chengdu 363 Hospital of Southwest Medical University, Chengdu City, Sichuan Province, China;2. Department of Neurosurgery, The Second People’s Hospital of Yibin City, Yibin City, Sichuan Province, China;1. United Diagnostic and Research Center for Clinical Genetics, Women and Children''s Hospital, School of Medicine & School of Public Health, Xiamen University, Xiamen, Fujian 361102, China;2. Genephile Bioscience Laboratory, Ko''s Obstetrics and Gynecology, Taipei 100, Taiwan, China;3. Biofast Biotechnology Co., Ltd., Xiamen, Fujian 361102, China;1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200240, China;2. Medical Science Laboratory, The Fourth Affiliated Hospital of Guangxi Medical University, Guangxi, 545005, China;3. Department of Hematology, The Fourth Affiliated Hospital of Guangxi Medical University, Guangxi, 545005, China;4. Department of Scientific Research and Education, The Fourth Affiliated Hospital of Guangxi Medical University, Guangxi, 545005, China;5. Department of Gastroenterology, The First People’s Hospital of Neijiang City, Sichuan, 641000, China;1. Department of Surgical Oncology, Shaanxi University of Chinese Medicine, Xi''an 710032, PR China;2. Xianyang Central Hospital, Xianyang 712000, PR China |
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| Abstract: | Numerous circular RNAs (circRNAs) have been identified as vital regulators in various cancers. The newly reported circular RNA ubiquitin-associated protein 2 (circUBAP2) is a critical player in cell growth and metastasis in various types of cancers, although its role in colorectal cancer (CRC) has yet to be fully elucidated. We find that circUBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. The effects of circUBAP2 on migration, invasion, and proliferation may be partially related to autophagy. Mechanistically, we uncover that circUBAP2 can directly interact with miR-582-5p and subsequently act as a microRNA sponge to regulate the expression of the miR-582-5p target gene forkhead box protein O1 (FOXO1) and downstream signaling molecules, which collectively advance the progression and metastasis of CRC. These results suggest that circUBAP2 acts as an oncogene via a novel circUBAP2/miR-582-5p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management. |
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| Keywords: | CircUBAP2 MiR-582-5p FOXO1 Autophagy Colon cancer |
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