Interaction of methyl-xanthines with myeloperoxidase. An anti-inflammatory mechanism. |
| |
| Authors: | J M van Zyl A Kriegler B J van der Walt |
| |
| Affiliation: | Department of Pharmacology, Faculty of Medicine, University of Stellenbosch, Tygerberg, South Africa. |
| |
| Abstract: | 1. Inhibition of myeloperoxidase (MPO)-catalyzed reactions by methyl-substituted xanthines has been investigated. 2. Except for theobromine and caffeine, all xanthines tested were potent inhibitors of the MPO-H2O2-Cl- system. 3. In contrast to methyl substitution in the 1 or 8 position of xanthine, substitution in the 3 or 7 position had a marked effect on the inhibition of MPO catalysis. 4. Two different inhibitory mechanisms were induced; scavenging of hypochlorous acid (HOCl) generated by the MPO system and accumulation of Compound II (ferryl MPO) which is inactive as a catalyst of Cl- oxidation. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
