Distribution of progestin-binding cells in estrogen-treated and untreated neonatal mouse uterus and oviduct: autoradiographic study with [125I]progestin |
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Authors: | R Murakami P J Shughrue W E Stumpf W Elger P -E Schulze |
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Institution: | (1) Department of Cell Biology and Anatomy, University of North Carolina, 27599 Chapel Hill, North Carolina, USA;(2) Research Laboratories, Schering AG, D-1000 Berlin 65, Federal Republic of Germany |
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Abstract: | Summary Progestin-binding sites in uteri and oviducts of estrogen-treated and untreated 8-day-old mice were studied by thaw-mount
autoradiography with 125I]progestin. In the untreated uteri, nuclear concentration of radiolabelled progestin was observed in all tissues of the uterus,
with strongest nuclear labelling in luminal and glandular epithelia and in stroma. In the estrogen-treated uteri, the degree
of labelling was markedly augmented in stroma and muscle, but much reduced in the luminal and glandular epithelia, compared
to untreated uteri. In untreated oviducts, nuclear labelling was observed in stroma and muscle in all regions and in epithelium
in the isthmic and uterine regions. The epithelium in infundibular and ampullar regions was only scarcely labelled. The estrogen-treatment
augmented the labelling in stroma and muscle of the oviduct as in the uterus, but the labelling in epithelium was not affected.
These results indicate that estrogen-treatment induces progesteron receptor differentially among tissue compartments both
in the uterus and oviduct. |
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