Mononuclear iron(III) complexes supported by tripodal N3O ligands: Synthesis, structure and reactivity towards DNA cleavage |
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| Authors: | Yee-Lok Wong Hoi Shan Kwan |
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| Affiliation: | a Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People’s Republic of China
b Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People’s Republic of China |
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| Abstract: | A new synthetic route to the known tripodal tetradentate N3O ligand L1 (HL1 = [N-(3,5-di-tert-butyl-2-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine) is reported. The related compounds HLn (n = 2, 3) were prepared by a similar procedure. Treatment of HLn (n = 1-3) with FeCl3·6H2O in hot methanol led to the mononuclear iron(III) complexes [Fe(Ln)Cl2] (1: n = 1, 2: n = 2, 3: n = 3). The solid-state structures of complexes 1 and 2 were determined by X-ray crystallography. [Fe(L1)Cl2] (1) showed effective nuclease activity in the presence of hydrogen peroxide, converting supercoiled plasmid DNA to its linear form. |
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| Keywords: | Iron complexes N-capped tripodal tetradentate N3O ligands Synthesis X-ray structures Electrochemistry Oxidative DNA cleavage activity |
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