Phase analysis of circadian-related genes in two tissues |
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| Authors: | Delong Liu Shyamal D Peddada Leping Li and Clarice R Weinberg |
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| Institution: | (1) Biostatistics Branch, National Institute of Environmental Health Sciences,MD: A3-03, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA;(2) CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709, USA |
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| Abstract: | Background Recent circadian clock studies using gene expression microarray in two different tissues of mouse have revealed not all circadian-related
genes are synchronized in phase or peak expression times across tissues in vivo. Instead, some circadian-related genes may be delayed by 4–8 hrs in peak expression in one tissue relative to the other.
These interesting biological observations prompt a statistical question regarding how to distinguish the synchronized genes
from genes that are systematically lagged in phase/peak expression time across two tissues. |
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