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Nickel(II) and zinc(II) dimonensinates: Single crystal X-ray structure, spectral properties and bactericidal activity |
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| Authors: | Ivayla N. Pantcheva Juliana Ivanova Mariana Mitewa Heike Mayer-Figge |
| Affiliation: | a Laboratory on Biocoordination and Bioanalytical Chemistry, Department of Analytical Chemistry, Faculty of Chemistry, Sofia University, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria b Medical Faculty, Sofia University, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria c Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bontchev Str., Build. 9, 1113 Sofia, Bulgaria d Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, D-44780 Bochum, Germany |
| Abstract: | Mononuclear transition metal complexes of the polyether ionophorous antibiotic monensin (monensic acid, MonH) with nickel(II) and zinc(II) were prepared and characterized using single crystal X-ray diffraction and spectral methods. Monensin complexes crystallize as [Ni(Mon)2(H2O)2]·H2O·5MeCN (1) and [Zn(Mon)2(H2O)2]·H2O·4.5MeCN (2), respectively, in the monoclinic space group P21. Compounds 1 and 2 consist of two monoanionic monensic acid ligands (monensinates) bound in a bidentate coordination mode to the transition metal ion. The metal center is placed in an octahedral environment with monensin anions occupying the equatorial plane of complexes via oxygens of carboxylate and hydroxyl groups located at the both ends of ionophore molecule. The strongly folded antibiotic anions are supported by intramolecular H-bonds, most of them originating from the two aqua ligands attached to the metal(II) ions in axial positions and completing their 6-fold coordination. The bioactivity assay reveals that the presence of divalent metal ion in the monensin complexes influences the biological properties of the ligand and should be taken into account when discussing its mode of action. |
| Keywords: | Monensin complexes Crystal structure Cytotoxicity Gram(+)-bacteria |
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