| lats基因在细胞周期和肿瘤发生中的作用 |
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| 引用本文： | 陈伟丽,邓可京,T. S. GREGORY,许田.lats基因在细胞周期和肿瘤发生中的作用[J].生物化学与生物物理进展,2001,28(6):811-814. |
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| 作者姓名： | 陈伟丽 邓可京 T. S. GREGORY 许田 |
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| 作者单位： | 1. 上海复旦大学生命科学院发育生物学实验基地,上海,200433
2. Howard Hughes Medical Institute,Yale University,School of Medicine,Department of Genetics,New Haven,CT 06536.USA |
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| 摘 要： | lats基因(large tumor suppressor gene)最早在果蝇中发现,在小鼠和人中均有同源基因.该基因的功能从果蝇到人是高度保守的.lats基因的功能包括:作为肿瘤抑制基因,其突变会导致肿瘤的发生;磷酸化的Lats与Cdc2结合,参与细胞周期的调控;通过细胞-细胞间的通讯,可能参与生物体个体大小的调控机制.从果蝇到人lats基因功能的研究,提供了以果蝇作为模式生物研究哺乳动物基因功能的方法.
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| 关 键 词： | lats基因 肿瘤抑制基因 肿瘤 细胞周期 细胞周期因子 大小调控 果蝇 模式生物 |
| 收稿时间： | 1/9/2001 12:00:00 AM |
| 修稿时间： | 2001年1月9日 |
lats Functon in Cell Cycle and Tumorigenesis |
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| CHEN Wei-Li,DENG Ke-Jing,T. S. GREGORY and XU Tian.lats Functon in Cell Cycle and Tumorigenesis[J].Progress In Biochemistry and Biophysics,2001,28(6):811-814. |
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| Authors: | CHEN Wei-Li DENG Ke-Jing T S GREGORY and XU Tian |
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| Institution: | School of Life Science, Developmental Experiment Base, Fudan University, Shanghai 200433, China;School of Life Science, Developmental Experiment Base, Fudan University, Shanghai 200433, China;Howard Hughes Medical Institute, Yale University, School of Medicine, Department of Genetics, New Haven, CT 06536. USA;Howard Hughes Medical Institute, Yale University, School of Medicine, Department of Genetics, New Haven, CT 06536. USA |
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| Abstract: | lats gene (large tumor suppressor gene), first identified in Drosophila melanogaster, has its homologues in mouse and human. The function of lats is highly conserved from Drosophila to human. Its function includes: as a tumor suppressor gene, lats mutation will result in a tumor phenotype; phosphorylated Lats can bind to Cdc2 and regulate cell cycle; Lats may also be involved in size control mechanism via cell-cell communication. The study of lats function from Drosophila to human can provide a method to study gene functions in mammals using Drosophila as a model organism. |
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| Keywords: | lats gene tumor suppressor gene tumor cell cycle cyclin size control Drosophila melanogaster model organism |
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