The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens |
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Authors: | Pavla Angelisová ?estmír Vl?ek Irena ?tefanová Marie Lipoldová Václav Ho?ej?í |
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Institution: | (1) Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Víde ská 1083, 142 20 Praha 4, Czechoslovakia |
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Abstract: | CD53 is an N-glycosylated pan-leucocyte antigen of 35–42 000 M
r. The sequence of the CD53 polypeptide deduced from a cDNA clone is 219 amino acids in length. It appears to lack a conventional leader sequence because the deduced NH2-terminal amino acid sequence is very similar to the rat MRC OX-44 and human CD37 antigens. The CD53 molecule is likely to consist of four transmembrane regions and a major extracellular hydrophilic loop containing two potential N-glycosylation sites. It is suggested that the CD53 glycoprotein is the true human homologue of the rat OX-44 antigen, rather than the CD37 antigen of more restricted expression and lower NH2-terminal sequence similarity to OX-44.The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number M37033.
Offprint requests to: P. Angelisová. |
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