Regulation of plasma levels of aldosterone and its metabolites during the latent period of aldosterone. |
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| Authors: | D J Morris R Tsai G A DeConti |
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| Affiliation: | 1. Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan;2. Division of Radiology, Teine Keijinkai Hospital, Sapporo, Japan;3. Division of Emergency and Critical Care Center, Teine Keijinkai Hospital, Sapporo, Japan;4. Division of Cardiovascular Center, Teine Keijinkai Hospital, Sapporo, Japan;1. Department of Cardiovascular Surgery, Surgical Research Center, GIGA-Cardiovascular Unit, University Hospital of Liège, Liège, Belgium;2. Laboratory of Connective Tissue Biology, GIGA-Cardiovascular Unit, University of Liège, Liège, Belgium;3. Surgical Research Center, GIGA-Cardiovascular Unit, University Hospital of Liège, Liège, Belgium;4. Department of Cardiovascular Surgery, University Hospital of Liège, Liège, Belgium;5. The Sigfried and Janet Weis Center for Research, Geisinger Health System Danville, PA;6. Department of Surgery, Temple University School of Medicine, Philadelphia, PA;1. Czech University of Life Sciences Prague, Faculty of Environmental Sciences, Department of Applied Geoinformatics and Spatial Planning, Kamýcká 129, 165 00 Prague 6, Czech Republic;2. Centre de Recherches sur la Biologie des Populations d’Oiseaux, UMR 7204 Centre d’Ecologie et des Sciences de la Conservation, CP 51, Muséum National d’Histoire Naturelle, 55 rue Buffon, F-75005 Paris, France;3. Institute for Environmental Studies, Charles University in Prague, Faculty of Science, Benatska 2, 128 01 Praha 2, Czech Republic;4. Laboratory of Ecosystem and Biodiversity Management, Department of Agriculture, Crop Production and Rural Environment, University of Thessaly, Fytokou str., N. Ionia, 38446 Volos, Greece;5. Centro Naturalistico Sammarinese, via Valdes De Carli 21, 47893 Borgo Maggiore, San Marino;6. Department of Zoology and Landscaping, University of Technology and Life Sciences, 85-225 Bydgoszcz, Poland;7. INRA, UMR 1048 SADAPT, F-75231 Paris, France;8. AgroParisTech, UMR 1048 SADAPT, F-75231 Paris, France;9. Swiss Federal Research Institute WSL, Biodiversity and Conservation Biology, Zürcherstrasse 111, 8903 Birmensdorf, Switzerland;10. Institute of Zoology, Poznan University of Life Sciences, Wojska Polskiego 71 C, PL-60-625 Poznań, Poland;1. College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China;2. The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, 325000, China;3. Departments of Pharmacology and toxicology, University of Louisville School of Medicine, Louisville, 40202, USA;4. School of Pharmacy, Temple University, Philadelphia, PA 19140, USA;5. Biopharmaceutical R&D Center of Jinan University, Guangzhou, Guangdong Province 510000, China;1. Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital and University of Turku, Turku, Finland;2. Heart Center, Turku University Hospital and University of Turku, Turku, Finland;3. Department of Radiology, Turku University Hospital and University of Turku, Turku, Finland |
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| Abstract: | Castration of male rats led to both increased biliary excretion of aldosterone metabolites and clearance of aldosterone radiometabolites from the plasma at rates similar to those of intact females and the elimination of the previously observed sex-dependence of these processes. Ovariectomy of female rats did not cause any effects in these processes. Treatment of both castrated male and ovariectomized female rats with testosterone reintroduced the sex-dependence so that the radiometabolites of aldosterone were cleared from the plasma and excreted via the bile of these animals at a slower rate typical of males. These findings suggest that the presence of androgens plays a major role in regulating the routes of hepatic metabolism of aldosterone, the subsequent rates of excretion of aldosterone metabolites via the bile and hence the concentration of aldosterone and the composition of the metabolites of aldosterone attained in the plasma during the latent period of the hormone.Hypophysectomy of femalerats significantly altered both the biliary excretion of aldosterone metabolites and the clearance from the plasma of aldosterone metabolites to rates typically observed in males. However, hypophysectomy of male rats did not cause changes in either of these two processes. These findings suggest that the presence of an intact pituitary is required for the sex-dependence of these processes in rats. |
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