Molecular cloning,nucleotide sequence and expression of a cDNA encoding an intracellular protein tyrosine phosphatase,PTPase-2, from mouse testis and T-cells |
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| Authors: | Hitoshi Miyasaka Steven S.-L. Li |
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| Affiliation: | (1) Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 27709 Research Triangle Park, North Carolina, USA |
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| Abstract: | The PTP-2 cDNA encoding an intracellular protein tyrosine phosphatase (PTPase-2) was isolated and sequenced from mouse testis and T-cell cDNA libraries. This PTP-2 cDNA was found to be homologous to human PTP-TC and rat PTP-S, and contained 1,551 nucleotides, including 1,146 nucleotides encoding 382 amino acids as well as 5 (61 nucleotides) and 3 (344 nucleotides) non-coding regions. Northern blot analysis indicated that PTP-2 mRNA of 1.9 Kb was most abundant in testis and kidney, although it was also present in spleen, muscle, liver, heart and brain.Abbreviations PTPase Protein Tyrosine Phosphatase (EC3.1.3.48) - PTKase Protein Tyrosine Kinase (EC2.7.1.112) |
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| Keywords: | mouse protein tyrosine phosphatase cDNA cloning nucleotide sequence gene expression |
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