Fractal nature of chromatin organization in interphase chicken erythrocyte nuclei: DNA structure exhibits biphasic fractal properties |
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| Authors: | Lebedev D V Filatov M V Kuklin A I Islamov A Kh Kentzinger E Pantina R Toperverg B P Isaev-Ivanov V V |
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| Affiliation: | Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Russia. |
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| Abstract: | Arrangement of chromatin in intact chicken erythrocyte nuclei was investigated by small angle neutron scattering. The scattering spectra have revealed that on the scales between 15 nm and 1.5 microm the interior of the nucleus exhibited properties of a mass fractal. The fractal dimension of the protein component of cell nucleus held constant at approximately 2.5, while the DNA organization was biphasic, with the fractal dimension slightly higher than 2 on the scales smaller than 300 nm and approaching 3 on the larger scales. |
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| Keywords: | SANS, small angle neutron scattering FISH, fluorescence in situ hybridization |
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