Unique homing properties of nonadherent peritoneal cells |
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| Authors: | R W Gillette C W Boone M H Swanson |
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| Institution: | 1. Melroy Laboratories, Inc., Springfield, VA, U.S.A.;2. Cell Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD U.S.A. |
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| Abstract: | The nonadherent lymphocytic cells from the peritoneum after 51Cr labeling and intravenous injection into normal syngeneic recipient mice were observed to distribute in a different manner from spleen and lymph node lymphocytes. These differences in dynamic behavior occurred despite the morphologic similarities of the cells. Such patterns of distribution were directly related to cell viability since heat-killed cells migrate in a distinctly different manner. Treatment of lymph node, spleen, and non-adherent peritoneal cells with anti-θ serum to eliminate T cells modified the dynamic behavior of all the cell populations somewhat, but did not eliminate major differences in the distribution patterns of nonadherent peritoneal “lymphocytes” compared to lymph node and splenic lymphocytes. The suggestion is made that the peritoneal lymphocyte differs from other lymphocytes. |
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