Genetic polymorphisms of 10 X-STR among four ethnic populations in northwest of China |
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Authors: | Ruifang Sun Yongsheng Zhu Feng Zhu Wenjian Kuang Jiali Feng Zhao Tian Zhaoqin Chai Yao Liu Shengbin Li |
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Institution: | (1) Key Laboratory of the National Ministry of Health for Forensic Sciences, College of Medicine, Xi’an Jiaotong University, 76 Yanta West Road, Xi’an, 710061, People’s Republic of China;(2) Key Laboratory of Environment and Gene Related Diseases, College of Medicine, Xi’an Jiaotong University, Ministry of Education, 76 Yanta West Road, Xi’an, 710061, People’s Republic of China;(3) Material Evidence Identification Center, Ministry of Public Security, Building 1, Nanli Muxudi, Xicheng, Beijing, 100038, People’s Republic of China;(4) Key Laboratory of Reproduction and Genetics of Ningxia Hui Autonomous Region, 1160 South Shengli Road, Yinchuan, 750004, People’s Republic of China; |
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Abstract: | In the present study, 10 short tandem repeats (STR) (HPRTB, DXS6789, DXS6799, DXS6804, DXS7130, DXS7132, DXS7133, DXS7423,
DXS7424, and DXS8378) on X chromosome were investigated among four ethnic populations (431 individuals) in northwest of China,
in order to learn about the genetic diversity, forensic suitability, and possible genetic affinities of the populations. The
polymorphism information content (PIC) values for the ten loci range from 0.340 to 0.810, and the observed heterozygosity
values for the ten loci range from 0.397 to 0.860, the results indicated that the ten loci have a moderate degree of variability
in the four populations, and each population has its own characteristics of genetic structure. A Neighbor-joining (NJ) tree
constructed on the basis of the generated data shows very low genetic distance between Han, Mongolian and Tibetan, Dongxiang
and Tu as well as between Salar and Bonan populations. Our results based on genetic distance analysis are consistent with
the results of earlier studies based on linguistics and the immigration history and origin of these populations. These STR
loci on the X chromosome studied here are not only useful in showing significant genetic variation between the populations,
but also are suitable for human identity testing among the four populations. |
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