Optical imaging of plastic changes induced by fear conditioning in the auditory cortex |
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Authors: | Yoshinori Ide Takashi Miyazaki Johan Lauwereyns Guy Sandner Minoru Tsukada and Takeshi Aihara |
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Institution: | (1) Tamagawa University Brain Science Institute, 6-1-1 Tamagawa-gakuen, Machida, Tokyo 194-8610, Japan;(2) TOPS Systems Corporation, Ibaraki 305-0032, Japan;(3) Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 819-0395, Japan;(4) Faculty of Medicine, Louis Pasteur University, Strasbourg, 67085, France;(5) Faculty of Engineering, Tamagawa University, Machida, Tokyo 194-8610, Japan |
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Abstract: | The plastic changes in the auditory cortex induced by a fear conditioning, through pairing a sound (CS) with an electric foot-shock
(US), were investigated using an optical recording method with voltage sensitive dye, RH795. In order to investigate the effects
of association learning, optical signals in the auditory cortex in response to CS (12 kHz pure tone) and non-CS (4, 8, 16 kHz
pure tone) were recorded before and after normal and sham conditioning. As a result, the response area to CS enlarged only
in the conditioning group after the conditioning. Additionally, the rise time constant of the auditory response to CS significantly
decreased and the relative peak value and the decay time constant of the auditory response to CS significantly increased after
the conditioning. This study introduces an optical approach to the investigation of fear conditioning, representational plasticity,
and the cholinergic system. The findings are synthesized in a model of the synaptic mechanisms that underlie cortical plasticity. |
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Keywords: | Auditory cortex Optical imaging Voltage sensitive dye Fear conditioning Plastic change |
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