| 催产素影响耳蜗内直流电位的机理初探 |
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| 引用本文： | 王坚,李倩虹.催产素影响耳蜗内直流电位的机理初探[J].中国应用生理学杂志,1993,9(1):13-15. |
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| 作者姓名： | 王坚 李倩虹 |
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| 作者单位： | 南京铁道医学院听觉生理学研究室，南京铁道医学院听觉生理学研究室，南京铁道医学院听觉生理学研究室，南京铁道医学院听觉生理学研究室 南京 210009，南京 210009，南京 210009，南京 210009 |
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| 摘 要： | 采用耳蜗外淋巴灌流技术,观察了外源性催产素(OXT,0.04U/ml)对蜗内直流电位(EP)的影响。发现OXT灌流导致直接记录的EP值(G-EP)有微小下降,但可明显增大EP的负相成分(N-EP,由5mmol/L哇巴因灌流产生)的绝对值。OXT的这种作用可被氯化筒箭毒(dTC)阻断橄榄耳蜗束的传出控制所取消。文中讨论了OXT对EP两种成分影响的可能机制。
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| 关 键 词： | 蜗内直流电位 催产素 哇巴因 筒箭毒 |
PRELIMINARY INVESTIGATION OF THE MECHANISM UNDERLYING THE EFFECT OF OXYTOCIN ON ENDOCOCHLEAR POTENTIAL |
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| Wang Jian,Li Qianhong,Dong Weijia,Chen Jisheng.PRELIMINARY INVESTIGATION OF THE MECHANISM UNDERLYING THE EFFECT OF OXYTOCIN ON ENDOCOCHLEAR POTENTIAL[J].Chinese Journal of Applied Physiology,1993,9(1):13-15. |
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| Authors: | Wang Jian Li Qianhong Dong Weijia Chen Jisheng |
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| Abstract: | Effects of oxytocin (OXT) (0.04U / ml) on enodocochlear potentials(EP) were investigated in guinea pigs by means of perilymph perfusion. It was found that the oxytocin infusion caused a slight decrease in the general value of EP (G-EP) and a significant increase in the absolute value of negative EP (N-EP) which was induced by 5 mmol/ L ouabain. The effect of oxytocin on N-EP could be abolished by d-tubocurarine (dTC), a blocker of efferent nerve of olivo-cochlear bundle. The mechanism underlying the changes in both components of EP induced by oxytocin is discussed. |
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| Keywords: | endocochlear potential oxytocin ouabain d-tubocurarine |
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