Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains |
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| Authors: | Cao Sheng-Li Feng Yu-Ping Jiang Yu-Yang Liu Shi-Ying Ding Guo-Yu Li Run-Tao |
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| Affiliation: | Department of Chemistry, Capital Normal University, Beijing 100037, China. caoshengli@tsinghua.org.cn |
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| Abstract: | A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC(50) value of 0.5 microM. |
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