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Metal binding ability of hypermodified nucleosides of t-RNA. Potentiometric and spectroscopic studies on the metal complexes of N-[(9-β-D-ribofuranosylpurin-6-yl)carbamoyl] threonine |
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| Authors: | Malgorzata Jezowska-Bojczuk Henryk Kozlowski Katalin Vrnagy Imre Svg Jolanta Swiatek Ryszard W Adamiak |
| Institution: | Institute of Chemistry, University of Wroclaw, Wroclaw, Poland Institute of Inorganic and Analytical Chemistry, Lajos Kossuth University, Debrecen, Hungary Department of Basic Medical Sciences, Medical Academy, Wroclaw, Poland Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland |
| Abstract: | Copper(II), nickel(II), zinc(II), manganese(II), and magnesium(II) complexes of t6A (N-9-β-D-ribofuranosylpurin-6-yl)carbamoyl] threonine and t6Ade (N6(threoninocarbonyl)adenine) were studied by potentiometric and spectroscopic methods. It was found that t6Ade has three dissociable protons in the accessible pH range (N1 and N9 of purine and carboxylate), while only two pK values are characteristic of t6A. Magnesium(II) and manganese(II) do not interact effectively with these ligands, but copper(II) and nickel(II) ions form very stable complexes with the coordination of purine N1, deprotonated amide nitrogen, and carboxy late oxygen donors. |
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