Analysis of family resemblance. IV. Operational characteristics of segregation analysis. |
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Authors: | C J MacLean N E Morton R Lew |
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Affiliation: | Population Genetics Laboratory, University of Hawaii, Honolulu 96822. |
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Abstract: | In simulated data, segregation analysis of quantitative traits was found to be powerful for resolving a major locus from polygenic and cultural inheritance. It is reasonably robust against a variety of deviations from the model if and only if a major locus, polygenic heritability, and environment common to sibs are simultaneously included in the model, and heterogeneity tests among mating types are performed. Most of the information in quantitative data about a major locus is lost when reduced to affection status. |
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