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血源乙肝疫苗人体反应及免疫效果观察报告
引用本文:盛友陇 温帼玲. 血源乙肝疫苗人体反应及免疫效果观察报告[J]. 微生物学免疫学进展, 1996, 24(3): 11-14
作者姓名:盛友陇 温帼玲
作者单位:卫生部兰州生物制品研究所
摘    要:对我所1985年以来生产的160批血源乙型肝炎疫苗进行了3680例的现场人体观察,结果表明该疫苗接种后,全身及局部反应轻微,在随访期间未显示任何乙型肝炎病毒感染证据;儿童3针免疫后3个月抗-HBs平均血清阳转率即达到98%以上,具有高度的免疫原性。

关 键 词:乙肝疫苗,安全性,抗体应答,阳转率

Evaluation of the Hepatitis B Vaccine in Field Trial
Sheng Youlong,Wen Guoling,Ren Kui. Evaluation of the Hepatitis B Vaccine in Field Trial[J]. Progress In Microbiology and Immunology, 1996, 24(3): 11-14
Authors:Sheng Youlong  Wen Guoling  Ren Kui
Abstract:We have observed the adverse reaction and the immunization efect of the Hepatitis B vaccine that prodced by lanzhou Institute of Biological products in field trial in recent years.It was observed in 3680 children aged from 3 to 20 years old.The results showed that the vaccine was highly immunogenic and safe for primary immunization.There were no any systemic reaction and the local adverse reaction was very slight in observation of 9 years.The mean of seroconversion of third month after vaccination were up to more than 98%.
Keywords:Hepatitis B vaccine Safety Antibody response Seroconversion rate
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