The uncoupling activity of substituted anthracene derivatives on isolated mitochondria from Phaseolus aureus |
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| Authors: | Edward H.C. Verhaeren |
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| Affiliation: | Laboratory of Pharmacognosy, Institute of Pharmaceutical Sciences, Katholieke Universiteit te Leuven, Leuven, Belgium |
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| Abstract: | Unsubstituted anthraquinones and anthrones have a low uncoupling activity on isolated mitochondria. The presence of phenolic groups is a prerequisite for a marked effect. The number of phenolic groups is of minor importance but their substitution pattern is important. The methylene group of the anthrones increases the activity. |
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| Keywords: | Fabaceae mitochondria anthracenes anthraquinones uncoupling activity. |
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