Schizonellin A and B,new glycolipids from Schizonella melanogramma |
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| Authors: | Günther Deml Timm Anke Franz Oberwinkler Bruno Max Giannetti Wolfgang Steglich |
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| Institution: | 1. Institut für Biologie I, Lehrstuhl Spezielle Botanik der Universität, Auf der Morgenstelle 1, D-7400 Tübingen, W. Germany;2. Institut für Organische Chemie und Biochemie der Universität, Gerhard-Domagk-Str. 1, D-5300, Bonn, W. Germany |
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| Abstract: | Two new glycolipids, schizonellin A and B, were isolated from cultures of the smut fungus Schizonella melanogramma. Their structures were elucidated by chemical degradation and spectroscopic methods. The schizonellins are active against Gram-positive bacteria, as well as against some Gram-negative bacteria and some fungi. DNA-, RNA- and protein-syntheses in Ehrlich carcinoma ascitic cells are inhibited simultaneously after addition of the schizonellins. Strong haemolytic action on bovine erythrocytes was observed. |
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| Keywords: | Basidiomycetes smut fungi antibiotics glycolipids schizonellins |
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