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Biotransformation of digitoxigenin by cell suspension cultures of Digitalis purpurea |
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| Authors: | Masao Hirotani Tsutomu Furuya |
| Affiliation: | School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108, Japan |
| Abstract: | Digitoxigenin was oxidized to digitoxigenone which was reduced to epidigitoxigenin and then glucosylated to epidigitoxigenin glucoside by cell cultures of Digitalis purpurea. The epidigitoxigenin glucoside, together with digitoxigenone and epidigitoxigenin, was isolated in considerable amounts, whereas digitoxigenin glucoside could only be detected in low concentration. Furthermore, it was confirmed by TLC and HPLC that digitoxigenin was hydroxylated to periplogenin. |
| Keywords: | Scrophulariaceae tissue cultures biotransformation hydroxylation glucosylation steroid digitoxigenin digitoxigenone epidigitoxigenin periplogenin digitoxigenin glucoside epidigitoxigenin glucoside. |
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