A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase |
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| Authors: | Yu X Y Hill J M Yu G Yang Y Kluge A F Keith D Finn J Gallant P Silverman J Lim A |
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| Institution: | Department of Medicinal Chemistry, Cubist Pharmaceuticals, Inc., Cambridge, MA 02139, USA. xiang@cubist.com |
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| Abstract: | A series of quinoline inhibitors of C. albicans prolyl tRNA synthetase was identified. The most potent analogue, 2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid, showed IC50 = 5 nM (Ca. ProRS) with high selectivity over the human enzyme. |
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