Kinetic resolution of rac-2-pentanol catalyzed by Candida antarctica lipase B in the ionic liquid, 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]amide |
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| Authors: | Marilyne Noël Pedro Lozano Michel Vaultier José L. Iborra |
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| Affiliation: | 1. Departamento de Bioquímica y Biología Molecular B e Inmunología, Facultad de Química, Universidad de Murcia, P.O. Box 4021, E-30100, Murcia, Espa?a
2. Institut de Chimie, UMR CNRS 6510, Campus de Beaulieu, Université de Rennes1, Av. Général Leclerc, 35042, Rennes, France
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| Abstract: | The ionic liquid, l-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]amide ([Bmim] [NTf2]), was used as a reaction medium for the kinetic resolution of rac-2-pentanol catalyzed by free Candida antarctica lipase B, using vinyl propionate at 2% (v/v) water content. The synthetic activity of lipase in [Bmim] [NTf2] was up 2.5-times greater than in hexane, and showed high enantioselectivity (ee > 99.99%). The optimal temperature and pH were 60 degrees C and 7, respectively. A decrease in water activity (aw) produced a decay in synthetic activity, and an exponential increase in selectivity. |
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| Keywords: | aw ionic liquids kinetic resolution lipase 2-pentanol |
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