Phyto-synthesis of silver nanoparticles using <Emphasis Type="Italic">Alternanthera tenella</Emphasis> leaf extract: an effective inhibitor for the migration of human breast adenocarcinoma (MCF-7) cells |
| |
| Authors: | Palanivel Sathishkumar Krishnan Vennila Rajarajeswaran Jayakumar Abdull Rahim Mohd Yusoff Tony Hadibarata Thayumanavan Palvannan |
| |
| Institution: | 1.Centre for Environmental Sustainability and Water Security (IPASA),Research Institute for Sustainable Environment (RISE), Universiti Teknologi Malaysia,UTM Skudai,Malaysia;2.Laboratory of Bioprocess and Engineering, Department of Biochemistry,Periyar University,Salem,India;3.Department of Molecular Medicine, Faculty of Medicine,University of Malaya,Kuala Lumpur,Malaysia;4.Department of Environmental Engineering, Faculty of Civil Engineering,Universiti Teknologi Malaysia,UTM Skudai,Malaysia |
| |
| Abstract: | In this study, phyto-synthesis of silver nanoparticles (AgNPs) was achieved using an aqueous leaf extract of Alternanthera tenella. The phytochemical screening results revealed that flavonoids are responsible for the AgNPs formation. The AgNPs were characterised using UV–visible spectrophotometer, field emission scanning microscopy/energy dispersive X-ray, transmission electron microscopy, fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction. The average size of the nanoparticles was found to be ≈48 nm. The EDX results show that strong signals were observed for the silver atoms. The strong band appearing at 1601–1595 cm?1 correspond to C–C stretching vibration from dienes in FT-IR spectrum indicating the formation of AgNPs. Human breast adenocarcinoma (MCF-7) cells treated with various concentrations of AgNPs showed a dose-dependent increase in cell inhibition. The IC50 value of the AgNPs was calculated to be 42.5 μg mL?1. The AgNPs showed a significant reduction in the migration of MCF-7 cells. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
