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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
Affiliation:1. Wellcome Centre Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK;2. Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 Amsterdam, the Netherlands;3. Oncode Institute, Meibergdreef 9, 1105 Amsterdam, the Netherlands;4. Swiss Institute for Bioinformatics, University of Lausanne, Lausanne, Switzerland;5. Cancer Research UK Beatson Institute, Glasgow, UK;6. Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, UK;7. Department of Oncology, Old Road Campus Research Building, Roosevelt Drive, University of Oxford, Oxford, UK;8. Department of Pathology and Molecular Pathology, University and University Hospital Zürich, Rämistrasse 100, 8006 Zürich, Switzerland;9. Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK;10. Academic Department of Surgery, University of Birmingham, Birmingham, UK;11. Candiolo Cancer Institute FPO IRCCS, 10060 Candiolo, Torino, Italy;12. University of Geneva and Department of Oncology, Hôpitaux Universitaires de Genève, Geneva, Switzerland;13. Molecular Digestive Oncology Unit, KU Leuven, Leuven, Belgium;14. Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK
Abstract:
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  • Keywords:stem cells  cell plasticity  colorectal neoplasia  molecular phenotyping  intestinal stem cells  intestinal polyps  colorectal cancer
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