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A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
Institution:1. Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden;2. Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA;3. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland;4. Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden;5. Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Lund, Sweden;6. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA
Abstract:
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  • Keywords:KRAB-ZNFs  human  chimpanzee  evolution  brain development  transposable elements  CRISPRi  forebrain neural progenitors
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