Effect of Neoadjuvant Chemotherapy in Patients with Resectable Colorectal Liver Metastases |
| |
Authors: | Dexiang Zhu Yunshi Zhong Ye Wei Lechi Ye Qi Lin Li Ren Qinghai Ye Tianshu Liu Jianmin Xu Xinyu Qin |
| |
Institution: | 1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.; 2. Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.; 3. Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.; Indiana University School of Medicine, United States of America, |
| |
Abstract: | BackgroundWhether patients with resectable colorectal liver metastases (CRLM) receive survival benefit from neoadjuvant chemotherapy remains controversial.MethodsWe retrospectively analyzed 466 patients with resectable CRLM between 2000 and 2010. Patient characteristics and survival data were recorded.ResultsThe patients were divided into one group with neoadjuvant chemotherapy (group NC, n = 121) and another without (group WN, n = 345). There was no difference in 5-year survival (52% vs. 48%) between the two groups. No significant differences were identified between the two groups in terms of 30-day mortality (1.7% vs. 1.2%) or morbidity (33.9% vs. 25.8%). A primary tumor at stage T4, ≥4 liver metastases, the largest liver metastasis ≥5 cm in diameter, and a serum CEA level ≥5 ng/ml were independent prognostic factors. By assigning one point to each, the patients were divided into a low-risk group (0–2) and a high-risk (3–4). The patients in the low-risk group received no survival benefit from neoadjuvant chemotherapy, whereas those in the high-risk group received survival benefit (5-year survival, 39% vs. 33%, P = 0.028).ConclusionsPreoperative neoadjuvant chemotherapy did not increase mortality or complications. Not all resectable patients, only those with >2 independent risk factors, received survival benefit from neoadjuvant chemotherapy. |
| |
Keywords: | |
|
|