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Diversity,biology, and history of psilocybin-containing fungi: Suggestions for research and technological development
Institution:1. Department of Wood Science and Engineering, Oregon State University, Corvallis, OR, 97333, USA;2. Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, 97333, USA;3. Department of Chemistry, Portland State University, Portland, OR, 97201, USA;4. Department of Biology, Portland State University, Portland, OR, 97201, USA;5. Department of Plant Pathology, Ohio State University, Columbus, OH, 43210, USA;6. Natural History Museum of Utah & School of Biological Sciences, University of Utah, Salt Lake City, UT, 84112, USA;7. Instituto de Biología, Universidad Nacional Autónoma de México, Coyoacán, Mexico City, 04510, Mexico
Abstract:Therapeutic use of psilocybin has become a focus of recent international research, with preliminary data showing promise to address a range of treatment-resistant mental health conditions. However, use of psilocybin as a healing entheogen has a long history through traditional consumption of mushrooms from the genus Psilocybe. The forthcoming adoption of new psilocybin-assisted therapeutic practices necessitates identification of preferred sources of psilocybin; consequently, comprehensive understanding of psilocybin-containing fungi is fundamental to consumer safety. Here we examine psilocybin producing fungi, discuss their biology, diversity, and ethnomycological uses. We also review recent work focused on elucidation of psilocybin biosynthetic production pathways, especially those from the genus Psilocybe, and their evolutionary history. Current research on psilocybin therapies is discussed, and recommendations for necessary future mycological research are outlined.
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