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Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation
Affiliation:1. Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands;2. The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, the Netherlands;3. Center of Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands;4. Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands;5. Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands;6. Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium;7. Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands;8. Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands
Abstract:
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  • Keywords:spatial dynamic metabolomics  multi-omics metabolomics  MALDI-MSI  fetal kidney development  hiPSC-derived kidney organoids  nephrogenesis  cell metabolism  single cell  proximal tubule development
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