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Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission
Institution:1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;2. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;3. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;4. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;5. Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA;6. QBI Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA;7. J. David Gladstone Institutes, San Francisco, CA 94158, USA;8. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158-2140, USA;9. Huffington Center for Cell-based Research in Parkinson’s Disease, Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA;10. Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA;11. Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;12. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;13. Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;14. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Abstract:
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  • Keywords:SARS-CoV-2  spike cleavage  H655Y mutation  variants of concern  syncytia formation  gamma  omicron  fusion
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