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A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise
Affiliation:1. Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK;2. Department of Hematology, University of Cambridge, Cambridge CB2 0AW, UK;3. National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0AW, UK;4. Skeletal Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA;5. NIH Oxford-Cambridge Scholars Program in Partnership with Medical University of South Carolina, Charleston, SC 29425, USA;6. Arthritis and Regenerative Medicine Laboratory, Aberdeen Centre for Arthritis and Musculoskeletal Health, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK;7. Instituto de Biomedicina de Sevilla-IBiS (Hospitales Universitarios Virgen del Rocío y Macarena/CSIC/Universidad de Sevilla), 41013 Seville, Spain;8. Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, 41009 Seville, Spain;9. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, (CIBERNED), Madrid 28029, Spain;10. Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur Alzette, Luxembourg;11. Department of Physiology, Development, and Neuroscience, Cambridge Advanced Imaging Centre, University of Cambridge, Cambridge CB2 3DY, UK;12. Institute of Clinical Neurobiology, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany;13. Cambridge NIHR Biomedical Research Centre, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK;14. UCB Pharma, 208 Bath Road, Slough SL1 3WE, UK;15. Department of Surgery, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, UK
Abstract:
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  • Keywords:cholinergic  sympathetic  osteocyte  autonomic  development  skeletal  bone  exercise  neuroskeletal  anabolic
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