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Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction
Institution:1. Division of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA;2. Division of Hematology and Medical Oncology, Department of Medicine, and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA;3. New York Genome Center, New York, NY, USA;4. Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA;5. Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA;6. Bioengineering Program, Fred DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, NY, USA;7. Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10065, USA;8. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA;9. Genomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA
Abstract:
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  • Keywords:vascular heterogeneity  endothelial cell specification  hepatic angiocrine factors  development  single-cell molecular profiling  fibrosis  c-Maf  single-cell RNAseq  postnatal maturation  endothelial cell reprogramming  liver sinusoidal endothelial cells
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