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An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling
Affiliation:1. Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;2. Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;3. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;4. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;5. Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S3G9, Canada;6. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S3E1, Canada;7. Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S3G5, Canada
Abstract:
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  • Keywords:muscle stem cell  satellite cell  quiescence  stem cell activation  Rac1  Rho  GTPase  cytoskeleton  mechanosignaling  stem cell niche
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