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Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
Affiliation:1. Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;2. Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany;3. Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany;4. Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, 60590 Frankfurt, Germany;5. Program in Immunology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA;6. Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;7. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London London EC1M 6BQ, UK;8. Institute of Molecular Medicine, Stem Cells and Aging, Aging Research Center, Ulm University, 89081 Ulm, Germany;9. Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA;10. Division of Applied Bioinformatics, DKFZ, 69120 Heidelberg, Germany;11. The German Cancer Consortium (DKTK), 69120 Heidelberg, Germany;12. Frankfurt Cancer Institute, 60590 Frankfurt, Germany;13. Section Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, 69120 Heidelberg, Germany;14. Division of Stem Cells and Cancer, DKFZ, 69120 Heidelberg, Germany;15. DKFZ-ZMBH Alliance, Heidelberg, Germany;16. Berlin Institute of Health (BIH), Charité Universitätsmedizin, 10178 Berlin, Germany;17. Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany;18. National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany;19. Faculty of Medicine, Otto-von-Guericke University, 39120 Magdeburg, Germany;20. Division of Inflammatory Stress in Stem Cells, DKFZ, 69120 Heidelberg, Germany;21. Division of Biostatistics, DKFZ, 69120 Heidelberg, Germany;22. Division of Chromatin Networks, DKFZ, 69120 Heidelberg, Germany;23. Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science and Medical Faculty, University of Augsburg, 86159 Augsburg, Germany;24. Bioinformatics and Omics Data Analysis, DKFZ, 69120 Heidelberg, Germany;25. Stem Cell Aging Group, Regenerative Medicine Program, The Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain;26. Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA;27. Cardio-Pulmonary Institute, 60590 Frankfurt, Germany
Abstract:
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  • Keywords:hematopoietic stem cells  HSCs  inflammation  stress hematopoiesis  aging  clonal hematopoiesis  self-renewal  accelerated aging  stem cell exhaustion  inflammaging
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